Roundup Linked to Global Boom in Celiac Disease and Gluten Intolerance

Posted on Feb 19 2014 - 12:14am by Sustainable Pulse

Celiac disease, gluten intolerance and irritable bowel syndrome are on the rise worldwide, and that rise has taken place in parallel with the increased use of glyphosate (Roundup) herbicide, shows a new US peer-reviewed paper from Dr. Anthony Samsel and Dr. Stephanie Seneff. The review has been published in the Journal of Interdisciplinary Toxicology.


Find Full Review Paper Here

Roundup is linked in Samsel and Seneff’s new review paper to a major increase in celiac disease. A recent estimate suggests that one in twenty people in North America and Western Europe now suffer from this gluten intolerant disease.

“All of the known biological effects of glyphosate – cytochrome P450 inhibition, disruption of synthesis of aromatic amino acids, chelation of transition metals, and antibacterial action – contribute to the pathology of celiac disease,” Samsel and Seneff’s paper states.

Monsanto’s Glyphosate (Roundup) has become the number one selling herbicide worldwide, due to the increase in the planting of Roundup Ready GM Crops.

What is Celiac Disease?

Celiac disease is a digestive disease that damages the small intestine and interferes with absorption of nutrients from food. People who have celiac disease cannot tolerate gluten, a protein in wheat, rye, and barley. Gluten is found mainly in foods but may also be found in everyday products such as medicines, vitamins, and lip balms.

When people with celiac disease eat foods or use products containing gluten, their immune system responds by damaging or destroying villi—the tiny, fingerlike protrusions lining the small intestine. Villi normally allow nutrients from food to be absorbed through the walls of the small intestine into the bloodstream. Without healthy villi, a person becomes malnourished, no matter how much food one eats.

Journal of Interdisciplinary Toxicology Review Abstract:

Authors: Dr. Anthony Samsel and Dr. Stephanie Seneff

Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North America and Europe, where an estimated 5% of the population now suffers from it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a multifactorial disease associated with numerous nutritional deficiencies as well as reproductive issues and increased risk to thyroid disease, kidney failure and cancer. Here, we propose that glyphosate, the active ingredient in the herbicide, Roundup®, is the most important causal factor in this epidemic. Fish exposed to glyphosate develop digestive problems that are reminiscent of celiac disease. Celiac disease is associated with imbalances in gut bacteria that can be fully explained by the known effects of glypho- sate on gut bacteria. Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450 enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with celiac disease can be attributed to glyphosate’s strong ability to chelate these elements. Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac disease match glyphosate’s known depletion of these amino acids. Celiac disease patients have an increased risk to non-Hodgkin’s lymphoma, which has also been implicated in glyphosate exposure. Reproductive issues associated with celiac disease, such as infertility, miscarriages, and birth defects, can also be explained by glyphosate. Glyphosate residues in wheat and other crops are likely increasing recently due to the growing practice of crop desiccation just prior to the harvest. We argue that the practice of “ripening” sugar cane with glyphosate may explain the recent surge in kidney failure among agricultural workers in Central America. We conclude with a plea to governments to reconsider policies regarding the safety of glyphosate residues in foods.

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27 Comments so far. Feel free to join this conversation.

  1. Al Klinge February 20, 2014 at 16:00 - Reply

    My father, an agriculture engineer, died of multiple myeloma; an immune system cancer…found to be directly related to toxins.
    stop the madness.. stop killing people.
    stop using roundup.

  2. Gluten Free America February 20, 2014 at 22:04 - Reply

    I have Celiac Disease and didn’t get rid of my symptoms until I went organic and completely off all grains, so this makes PERFECT sense to me and my personal experience. I also didn’t start having acute Celiac symptoms until the mid 1990′s. Coincidence? I don’t think so!

  3. t February 21, 2014 at 21:29 - Reply

    So, Gluten Free America, if you went organic AND grain free, how can you be certain that the reduction conventionally grown foods is the cure, and not the obvious one – reduction of gluten in your diet?

  4. Sally Ellis, PhD February 22, 2014 at 05:24 - Reply

    Seneff seems to make a habit of generating hundreds of speculations in her many papers, but seems to be averse to collaborating with any actual experimental scientists who could help her understand basic concepts in chemistry and biology, let alone the intricacies of toxicology, statistics or celiac disease. At this point, it can’t be a coincidence. This latest paper adds to her shame, but I’m sure it will be welcomed by people who will be impressed by how long it is.

    It is rare to come across someone with so little curiosity about whether their speculations are actually true! Real science works by formulating a hypothesis based on an OBJECTIVE review of the current knowledge, and then designing tests that could prove or invalidate the hypothesis. In all her writing, I have never once seen her formulate a testable hypothesis. Perhaps a couple of undergraduate or continuing ed. classes could help?

    • Robert Johnson PhD February 26, 2014 at 07:20 - Reply

      “Sally Ellis, PhD” is the type of post which is propounded by the marketing departments of chemicals manufacturers.

    • Marcus Kool, March 2, 2014 at 21:46 - Reply

      Hi Sally, your comment is worthless unless you stop talking in general terms and get to the point.

  5. Kelly February 24, 2014 at 03:49 - Reply

    I am so relieved to read this. I was just talking with my husband about how I know there was more to my problem than just gluten. Makes so much sense to me. I will be letting all my friends know about this. Thanks!

  6. McNamara February 24, 2014 at 16:23 - Reply

    Autoimmune Disease of the digestive tract is alarming trending upward as detailed in this report stating a

    71% increase in Autoimmune Disease of the intestine in American Children since 2000~

  7. Liam Chambers February 24, 2014 at 16:39 - Reply

    Good old Sally, predictable as always; attack the messenger, but ignore the message.We need independent peer-reviewed scientific research over the life time of consuming organisms ( e.g. Serelini’s 2 year study on rats), not commercially driven pseudo-science from Monsanto et al. Don’t become a lackey, Sally

  8. Lori February 24, 2014 at 21:37 - Reply

    I followed the link and read the article by Samsel and Seneff. While the subject may be worthy of further study, this work lacks any real credibility. Samsel is a retired scientist/consultant with no current institutional affiliation and Seneff is a research scientist at MIT in Computer Science and Artificial Intelligence, with no background in cell biology, biochemistry, or metabolism. In my mind, they are more activists than subject matter experts. While activism is fine, they shouldn’t be making scientific claims. Their article was published in the journal “Interdisciplinary Toxicolgy”, which, though peer reviewed, is published in Slovakia. This is a red flag in my mind. In the article, the authors explain how Roundup works and how it can theoretically disrupt digestion and metabolism in humans, but it is apparent that they have not done anything tangible (experiments, computer modeling, etc.) to study this phenomenon. They published a similar study last year in “Entropy”, but this is not a peer reviewed journal, and many scientists took issue with this article and discredited the work. Until there is an actual study on this subject rather than speculation, my feeling is that this is junk science.

    • Jason February 26, 2014 at 19:15 - Reply

      Not sure why you would say Slovakia is a “red flag”. You should read up on a country before you throw it under a bus. EU Member, excellent economy, strong education, plenty of scientists and research going on there. My guess is it was published in that Journal because it was a study in a field the authors typically don’t practice in. Agree that it needs some work to be a better scientific paper, but to discount someone’s work because it is outside their awarded degree is nonsense. That is why papers are peer reviewed. Science is science and one field uses the same method (Scientific) as the other. They can lean on SMEs from within a field they are not as familiar with and often do for research papers. Most everyone agrees that adding these man made chemicals to our systems tends to lead to bad results. I hope this sparks interest in some other scientists to close the loop and put an experiment together. Somehow I bet Monsanto won’t allow it though.

    • Leisa February 27, 2014 at 23:24 - Reply

      Everyone with a brain knows that mainstream peer reviewed scientific journals
      are bought and paid for by big business.

      Do you expect us to believe that because this article was published
      in Slovakia that it negates the looming evidence that chemicals
      are having a negative effect on people’s immune systems?
      I have Celiac Disease and I greatly appreciate this study.
      Do you have Celiac Disease?

  9. molecule February 26, 2014 at 01:23 - Reply

    Glyphosate is not a weed herbicide. It is not a broad spectrum herbicide.

    When Monsanto applied for the patent on glyphosate, they characterized the chemical as an antibiotic.

    Let’s learn the difference an herbicide and a broad spectrum antibiotic, and stop referring to Roundup as a herbicide.

    Glyphosate is patented as an antibiotic, is totally unregulated, and it applied to our soils, food and groundwater, by the millions of tons. Meanwhile, when grandma gets an infecftion, doctors tell us she can’t have a few milligrams of antibiotic, because we’re using too much on elderly people, and it might contaminate the rivers.

    There are interviews with Dr. Don Huber, PhD, on youtube wherein he characterizes glyphosate as the most powerful antibiotic that has ever been unleashed by man. It is a broad spectrum antibiotic, and it eventually kills everything.

  10. André Talbot February 26, 2014 at 21:22 - Reply

    While I am a proponent of precautionary approaches to toxic substances (only use them when they are demonstrated to be necessary and safe), I must agree that this article contains several serious flaws and does not provide reasonable link between glyphosate and digestive track disorders. Many many such correlations are possible and easy to graph. Serious research is required to corroborate what the authors propose.

  11. John February 28, 2014 at 22:15 - Reply

    I thought I was Guten intolerant. Then I realize I CAN eat Caputo 00 flour from Italy with no problems. Any Flour I get in the US destroys me the very next day for a week, severe acid reflux and bleeding IBS. This could be an explanation if they dont use roundup in Italy at least for me.

  12. Russell Rawlings March 1, 2014 at 17:27 - Reply

    If this is found to be true the extentent of global genocide on Monsanto’s behalf will make the holocaust look like a minor accident! Start thinking and sharing this study cause this one is a biggie.

  13. JR March 3, 2014 at 15:10 - Reply

    This is an important paper. Here’s hoping it will shine a spotlight onto the insane practice of poisoning the food we eat. Even if you discounted the science (which seems sound having read the full paper) you’d have to question the ethics of allowing entire populations to consume foods loaded with glyphosate residues. This report is the tip of the iceberg. Just do a google search to see a list of chemicals applied to foods in your country. I’m an Australian and a celiac & I’m appalled at the cocktail of poisons farmers are pouring onto and into our foods each day. Just look at this for starters: Sadly our government does not support organic farmers so unless we grow our own everything there’s little hope of remaining healthy.

  14. Kathy March 3, 2014 at 19:23 - Reply

    The article contains over 180 references to other scientific research papers Jason, Lori and Sally – probably all the same person. The article only discusses the problems with glyphosate, it doesn´t include much about the health problems caused by genetically modified foods as well.

  15. Bob March 3, 2014 at 19:27 - Reply

    Stephanie Seneff is a Senior Research Scientist at the MIT Computer Science and Artificial Intelligence Laboratory. She received the B.S. degree in Biophysics in 1968, the M.S. and E.E. degrees in Electrical Engineering in 1980, and the Ph.D degree in Electrical Engineering and Computer Science in 1985, all from MIT. For over three decades, her research interests have always been at the intersection of biology and computation – developing a computational model for the human auditory system, understanding human language so as to develop algorithms and systems for human computer interactions, as well as applying natural language processing (NLP) techniques to gene predictions. She has published over 170 refereed articles on these subjects, and has been invited to give keynote speeches at several international conferences. She has also supervised numerous Master’s and PhD theses at MIT. In 2012, Dr. Seneff was elected Fellow of the International Speech and Communication Association (ISCA).

    In recent years, Dr. Seneff has focused her research interests back towards biology. She is concentrating mainly on the relationship between nutrition and health. Since 2011, she has written 10 papers (7 as first author) in various medical and health-related journals on topics such as modern day diseases (e.g., Alzheimer, autism, cardiovascular diseases), analysis and search of databases of drug side effects using NLP techniques, and the impact of nutritional deficiencies and environmental toxins on human health.

  16. Normusa March 3, 2014 at 21:27 - Reply

    I do not think that Roundup is the direct culprit in this. I suspect that the GMO corn, wheat and other “Roundup ready” food are making the changes in our digestive systems. In Europe, as I understand it, GMO labeling is required and people avoid these products and little farming is done with GMO seed for this reason. In the US, GMO seed is pushed and protected by the government and we are subjected to GMO products in practically all processed foods. I do not think you can completely avoid GMO food unless you quit eating in restaurants, with friends and never use products that are packaged or bottled commercially.

    It is my belief that the GMO foods that we consume, especially GMO corn and wheat, are doing something to kill the bacteria that we need to digest food. I have tried to avoid white flour as is just starch and no nutrition left. Sugar is half GMO sugar beets so I avoid that and (GMO) high fructose corn syrup. I don’t think sugar cane is GMO. I try to eat organic as much as possible. Thus far, I do not have any allergies or intolerances (except to liberal-left politics)–I am 73.

  17. Jon B. Abrahamson March 4, 2014 at 03:19 - Reply

    Genetically Modified Organisms and the deterioration of health in the United States
    N.L. Swanson, 4/24/

    Official Statistics from the CDC, FDA, NIH, & SEER-9

  18. Keven March 4, 2014 at 04:14 - Reply

    Hello people. I would like to say that it is very easy to attack ranchers and farmers in the U.S. When only less than two percent of the population actually does the work that feeds millions and millions of people. It makes it very easy to distort real facts. In America we spend less than 10% of our income on food. The lowest of any nation in the world. These GMOs and roundup allow us to grow the amount of food that we do. I myself can not eat gluten. When I do it feels like there is a knife cutting my stomach, but I am ok with that, because we can feed more and more people even if I can’t eat it. I can always eat corn. I also have Ulcerative colitis so I understand what pain is.

  19. NaturalStatePureLiving March 6, 2014 at 18:22 - Reply

    Good read. Sad, but true. Everyone needs to have their own personal health strategy to combat the effects of all the numerous toxins that we are exposed to on a daily basis. Funny how most of us follow a maintenance schedule for our vehicles to change oil, fluids, filters on a regular basis – but don’t regularly detox our own bodies! Cleanse, balance and build is the key to my health strategy.

  20. Kathryn March 15, 2014 at 06:51 - Reply

    As a sufferer of gluten intolerance with allergies to corn and soy and peanuts plus others I have worked to up my ferritin level pre-total knee replacement to little effect. Please look at the CDC obesity levels and the USGS herbicide/pesticide maps over time — you will see the connection. Thanks to these authors for helping me understand my own circumstance.

  21. Barbara April 8, 2014 at 18:13 - Reply

    Whether Round-Up is the cause of celiac disease or any other health problem in humans is an argument that you can carry on ad nauseum. That anyone would choose to ingest chemicals of any kind that shut down the detoxification capabilities of one’s liver is INSANE. And we know that ROUND UP does this!. The purpose of the liver is to get the toxins out and RoundUp interfere’s with this. Round Up (and many other chemicals) is to the liver what saturated fats are to the heart. If ” cytochrome P450 inhibition, disruption of synthesis of aromatic amino acids, chelation of transition metals, ” cannot be disputed it doesn’t really matter to me what specific disease links can be established. A standard essay question given to med students is to argue which organ is more important to the body: the liver or the heart.

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